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KMID : 0931320150150020108
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대한상부위장관.헬리코박터학회지
2015 Volume.15 No. 2 p.108 ~ p.111
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Recent First Line Eradication Rate of Helicobacter pylori Infection: Single Center Experience
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신승민:Shin Seung-Min
임윤정:Lim Yun-Jeong/윤여진:Yoon Yeo-Jin/강현우:Kang Hyoun-Woo/김재학:Kim Jae-Hak/이준규:Lee Jun-Kyu/고문수:Koh Moon-Soo/이진호:Lee Jin-Ho
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Abstract
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Background/Aims: For more than a decade, triple therapy (proton pump inhibitor, amoxicillin, clarithromycin) has been the first line eradication regimen for Helicobacter pylori infection in Korea. However, recent studies have proven that its’ efficacy is no longer tolerable due to increased resistance of antibiotics. This study is aimed to investigate the current status of triple therapy, quadruple therapy and dual therapy as first line regimen for H. pylori infection in single medical center.
Materials and Methods: Medical records of patients who received urea breath test after first line eradication therapy from August 2011 to November 2014 were retrospectively analyzed. Patients were divided into three groups according to the first line treatment regimen; triple therapy (proton pump inhibitor (PPI)+clarithromycin+amoxicillin), quadruple therapy (PPI+bismuth+tetracycline+metronidazole), dual therapy (PPI+amoxicillin).
Results: A total of 557 patients were reviewed and 429 patients (77.0%) had successful eradication. Among 511 patients who received triple therapy, the eradication rates were 77.1% (394 patients). Eradication rates were 95.2% among quadruple therapy group. Dual therapy group had exceptionally low eradication rates (60.0%).
Conclusions: Even though triple therapy has been recommended as first line regimen in Korea, eradication rates were below 80%. Quadruple therapy as first line regimen showed promising future reaching over 90% eradication rates. However, due to the small number of patients in our study, further studies are necessary to estimate usefulness of quadruple therapy as first line regimen.(Korean
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KEYWORD
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Helicobacter pylori, Eradication, Triple therapy, Quadruple therapy
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